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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-3-25
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pubmed:abstractText |
Dumbbell-like Au-Fe(3)O(4) nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin-Au-Fe(3)O(4)-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC(50)) toward Sk-Br3 cells of 1.76 microg of Pt/mL, which is lower than that needed for cisplatin (3.5 microg/mL). The work demonstrates that the dumbbell-like Au-Fe(3)O(4) NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1520-5126
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4216-7
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pubmed:dateRevised |
2010-9-22
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pubmed:meshHeading |
pubmed-meshheading:19275156-Antineoplastic Agents,
pubmed-meshheading:19275156-Cell Line, Tumor,
pubmed-meshheading:19275156-Cisplatin,
pubmed-meshheading:19275156-Drug Carriers,
pubmed-meshheading:19275156-Drug Delivery Systems,
pubmed-meshheading:19275156-Drug Screening Assays, Antitumor,
pubmed-meshheading:19275156-Gold,
pubmed-meshheading:19275156-Humans,
pubmed-meshheading:19275156-Inhibitory Concentration 50,
pubmed-meshheading:19275156-Iron,
pubmed-meshheading:19275156-Materials Testing,
pubmed-meshheading:19275156-Metal Nanoparticles,
pubmed-meshheading:19275156-Nanostructures,
pubmed-meshheading:19275156-Nanotechnology,
pubmed-meshheading:19275156-Solubility
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pubmed:year |
2009
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pubmed:articleTitle |
Dumbbell-like Au-Fe3O4 nanoparticles for target-specific platin delivery.
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pubmed:affiliation |
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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