Linked Life Data

19274705

Source:http://linkedlifedata.com/resource/pubmed/id/19274705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-10-5
pubmed:abstractText
The aims of this study were to test a locally applied carvacrol gel and determine its efficacy preventing alveolar bone loss in experimental periodontitis in rats by regular methodology to validate applicability the atomic force microscopy (AFM) as a novel morphology method on this model. Wistar rats were subjected to ligature around second, upper-left molars. Animals were treated carvacrol gel topically (CAG), immediately after Experimental Periodontitis Disease induction for 1' three-times/day for 11 days. A vehicle gel was utilized as control. The periodontium and the surrounding gingivae were examined at regular histopathology and by AFM method; the neutrophil influx into the gingivae was also assayed using myeloperoxidase activity. The bacterial flora was assessed through culture of the gingival tissue. Alveolar bone loss was significantly inhibited by CAG group compared to the Vehicle (V) group, the carvacrol gel treatment reduced tissue lesion at histopathology, with preservation of the periodontium, coupled to decreased myeloperoxidase activity in gingival tissue and also prevented the proliferation of periodontal microorganisms and the weight loss. The GAC treatment preserved alveolar bone resorption and showed anti-inflammatory and antibacterial activities in experimental periodontitis. Topographical changes in histological sections were seen bringing into high relief the periodontal structures, being a simple and cost-effective method for periodontal evaluation with ultrastructural resolution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1099-1573
pubmed:author
pubmed:copyrightInfo
(c) 2009 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1439-48
pubmed:meshHeading
pubmed-meshheading:19274705-Administration, Topical, pubmed-meshheading:19274705-Alveolar Bone Loss, pubmed-meshheading:19274705-Animals, pubmed-meshheading:19274705-Anti-Bacterial Agents, pubmed-meshheading:19274705-Anti-Inflammatory Agents, pubmed-meshheading:19274705-Bacteria, pubmed-meshheading:19274705-Disease Models, Animal, pubmed-meshheading:19274705-Gels, pubmed-meshheading:19274705-Gingiva, pubmed-meshheading:19274705-Ligation, pubmed-meshheading:19274705-Male, pubmed-meshheading:19274705-Microscopy, Atomic Force, pubmed-meshheading:19274705-Molar, pubmed-meshheading:19274705-Monoterpenes, pubmed-meshheading:19274705-Neutrophil Infiltration, pubmed-meshheading:19274705-Periodontitis, pubmed-meshheading:19274705-Periodontium, pubmed-meshheading:19274705-Peroxidase, pubmed-meshheading:19274705-Rats, pubmed-meshheading:19274705-Rats, Wistar
pubmed:year
2009
pubmed:articleTitle
Protective effect of locally applied carvacrol gel on ligature-induced periodontitis in rats: a tapping mode AFM study.
pubmed:affiliation
Laboratory of Chemistry Technology, Federal Institute of Education, Science and Technology of Ceará, Fortaleza, Ceará, Brazil. marcobotelho1@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Validation Studies