| pubmed-article:19274064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19274064 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:19274064 | lifeskim:mentions | umls-concept:C0900627 | lld:lifeskim |
| pubmed-article:19274064 | lifeskim:mentions | umls-concept:C1333226 | lld:lifeskim |
| pubmed-article:19274064 | lifeskim:mentions | umls-concept:C1705335 | lld:lifeskim |
| pubmed-article:19274064 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19274064 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19274064 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19274064 | pubmed:dateCreated | 2009-5-7 | lld:pubmed |
| pubmed-article:19274064 | pubmed:abstractText | The present study aims to define the role of postsynaptic density (PSD)-95 in the regulation of dopamine (DA) receptor function. We found that PSD-95 physically associates with either D(1) or D(2) DA receptors in co-transfected HEK-293 cells. Stimulation of DA receptors altered the association between D(1) receptor and PSD-95 in a time-dependent manner. Functional assays indicated that PSD-95 co-expression did not affect D(1) receptor-stimulated cAMP production, Gs-protein activation or receptor desensitization. However, PSD-95 accelerated the recovery of internalized membrane receptors by promoting receptor recycling, thus resulting in enhanced resensitization of internalized D(1) receptors. Our results provide a novel mechanism for regulating DA receptor recycling that may play an important role in postsynaptic DA functional modulation and synaptic neuroplasticity. | lld:pubmed |
| pubmed-article:19274064 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19274064 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19274064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19274064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19274064 | pubmed:month | May | lld:pubmed |
| pubmed-article:19274064 | pubmed:issn | 1748-7838 | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:ZhengJieJ | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:ChengWeiW | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:FriedmanEitan... | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:ZhenXuechuX | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:JinGuo-zhangG... | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:SunPeihuaP | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:WangJingruJ | lld:pubmed |
| pubmed-article:19274064 | pubmed:author | pubmed-author:GuWeihuaW | lld:pubmed |
| pubmed-article:19274064 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19274064 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19274064 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19274064 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19274064 | pubmed:pagination | 612-24 | lld:pubmed |
| pubmed-article:19274064 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:meshHeading | pubmed-meshheading:19274064... | lld:pubmed |
| pubmed-article:19274064 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19274064 | pubmed:articleTitle | PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation. | lld:pubmed |
| pubmed-article:19274064 | pubmed:affiliation | State Key Laboratory of Drug Research, Department of Neuropharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. | lld:pubmed |
| pubmed-article:19274064 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19274064 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19274064 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:1742 | entrezgene:pubmed | pubmed-article:19274064 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19274064 | lld:entrezgene |
