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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-6-30
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pubmed:abstractText |
Carbamoyl phosphate synthetase-I (CPS1) is a key enzyme in the urea cycle and patients with defects in the function or expression of CPS1 suffer from hyperammonemia. CPS1 is expressed in the liver at neonatal and adult stages in a CCAAT enhancer-binding protein-alpha (C/EBPalpha)-dependent manner. Despite expression of C/EBPalpha, CPS1 is not expressed in fetal liver, indicating an additional factor is involved in the regulation of CPS1 expression. The aim of this study was to elucidate the mechanism of CPS1 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
330-40
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19272383-Age Factors,
pubmed-meshheading:19272383-Ammonia,
pubmed-meshheading:19272383-Animals,
pubmed-meshheading:19272383-Animals, Newborn,
pubmed-meshheading:19272383-Base Sequence,
pubmed-meshheading:19272383-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:19272383-Carbamoyl-Phosphate Synthase (Ammonia),
pubmed-meshheading:19272383-Cells, Cultured,
pubmed-meshheading:19272383-Disease Models, Animal,
pubmed-meshheading:19272383-Down-Regulation,
pubmed-meshheading:19272383-Drug-Induced Liver Injury,
pubmed-meshheading:19272383-Gene Expression Profiling,
pubmed-meshheading:19272383-Gene Expression Regulation, Developmental,
pubmed-meshheading:19272383-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:19272383-Genes, Reporter,
pubmed-meshheading:19272383-Gestational Age,
pubmed-meshheading:19272383-Hepatocytes,
pubmed-meshheading:19272383-Humans,
pubmed-meshheading:19272383-Liver,
pubmed-meshheading:19272383-Mice,
pubmed-meshheading:19272383-Mice, Inbred C57BL,
pubmed-meshheading:19272383-Molecular Sequence Data,
pubmed-meshheading:19272383-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19272383-Promoter Regions, Genetic,
pubmed-meshheading:19272383-Protein Binding,
pubmed-meshheading:19272383-Time Factors,
pubmed-meshheading:19272383-Transcription, Genetic,
pubmed-meshheading:19272383-Transcription Factors,
pubmed-meshheading:19272383-Transduction, Genetic,
pubmed-meshheading:19272383-Urea
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pubmed:year |
2009
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pubmed:articleTitle |
Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice.
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pubmed:affiliation |
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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