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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-4-1
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pubmed:abstractText |
Interferon (IFN)-induced signalling pathways have essential functions in innate immune responses. In response to type I IFNs, filamin B tethers RAC1 and a Jun N-terminal kinase (JNK)-specific mitogen-activated protein kinase (MAPK) module--MEKK1, MKK4 and JNK--and thereby promotes the activation of JNK and JNK-mediated apoptosis. Here, we show that type I IFNs induce the conjugation of filamin B by interferon-stimulated gene 15 (ISG15). ISGylation of filamin B led to the release of RAC1, MEKK1 and MKK4 from the scaffold protein and thus to the prevention of sequential activation of the JNK cascade. By contrast, blockade of filamin B ISGylation by substitution of Lys 2467 with arginine or by knockdown of ubiquitin-activating enzyme E1-like (UBEL1) prevented the release of the signalling molecules from filamin B, resulting in persistent promotion of JNK activation and JNK-mediated apoptosis. These results indicate that filamin B ISGylation acts as a negative feedback regulatory gate for the desensitization of type I IFN-induced JNK signalling.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-10224076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-11157743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-11252955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-11336782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-11788588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-11839738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-15131269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-15485925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-15864272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-16009940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-16352599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-16375603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-16815975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-16914094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-16979568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-17719635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-18057259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-18287095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-18305167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-18815275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-19305389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-2440890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-9162520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-9326655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-9861020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-9918882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19270716-9927514
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contractile Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/ISG15 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/UBE2L6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Conjugating Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitins,
http://linkedlifedata.com/resource/pubmed/chemical/filamins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1469-3178
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pubmed:author |
pubmed-author:BangOk SunOS,
pubmed-author:ChoiJoon SeokJS,
pubmed-author:ChungChin HaCH,
pubmed-author:JeonYoung JooYJ,
pubmed-author:KaSeung HyeunSH,
pubmed-author:KimKeun IlKI,
pubmed-author:KimSangman MichaelSM,
pubmed-author:LeeJung YunJY,
pubmed-author:OhKyu HeeKH,
pubmed-author:YuKyung RyunKR,
pubmed-author:ZhangDong-ErDE
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
374-80
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pubmed:dateRevised |
2010-9-22
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pubmed:meshHeading |
pubmed-meshheading:19270716-Apoptosis,
pubmed-meshheading:19270716-Cell Line,
pubmed-meshheading:19270716-Contractile Proteins,
pubmed-meshheading:19270716-Cytokines,
pubmed-meshheading:19270716-HeLa Cells,
pubmed-meshheading:19270716-Humans,
pubmed-meshheading:19270716-Immunoprecipitation,
pubmed-meshheading:19270716-Interferon Type I,
pubmed-meshheading:19270716-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:19270716-Microfilament Proteins,
pubmed-meshheading:19270716-Models, Biological,
pubmed-meshheading:19270716-Signal Transduction,
pubmed-meshheading:19270716-Ubiquitin-Conjugating Enzymes,
pubmed-meshheading:19270716-Ubiquitins
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pubmed:year |
2009
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pubmed:articleTitle |
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.
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pubmed:affiliation |
School of Biological Sciences, Seoul National University, 56-1 Shillim-dong, Kwanak-gu, Seoul 151-742, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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