Linked Life Data

19270232

Source:http://linkedlifedata.com/resource/pubmed/id/19270232

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-3-9
pubmed:abstractText
Proteolysis products of proteins damaged by glycation, oxidation, and nitration-glycated, oxidized, and nitrated amino acids (glycation, oxidation, and nitration free adducts)-are waste products normally excreted in urine and cleared in peritoneal dialysate. Glucose degradation products in peritoneal dialysis (PD) fluids may increase protein damage, giving rise to increased protein glycation, oxidation, and nitration adduct residues of proteins and increased flux of glycation, oxidation, and nitration free adducts. Increased protein damage has been linked to mortality in end-stage renal disease. Reliable quantitation of markers for adducts of protein glycation, oxidation, and nitration is required for mechanistic studies and for morbidity and mortality risk analysis in PD patients. We review the available analytical techniques for such quantitation. Stable isotopic dilution analysis with tandem mass spectrometry is the "gold standard." This method needs to be applied further in the study of PD and to validate other techniques so that the effect of PD on the metabolism and clearance of damaged proteins and related products can be quantified, and so that best-practice fluid management can be established to minimize cardiovascular risk.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0896-8608
pubmed:author
pubmed:issnType
Print
pubmed:volume
29 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S51-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Quantitation of markers of protein damage by glycation, oxidation, and nitration in peritoneal dialysis.
pubmed:affiliation
Warwick Medical School, Clinical Sciences Research Institute, University of Warwick, University Hospital, Coventry, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't