Linked Life Data

19269255

Source:http://linkedlifedata.com/resource/pubmed/id/19269255

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pubmed-article:19269255pubmed:abstractTextThe pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFbeta1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TGFbeta1 in DHF by analyzing them for association with virus load in blood and polymorphisms of CTLA-4 +49A/G, and TGFbeta1 -509C/T in a DEN-2 outbreak. The increased frequency of the TGFbeta1 -509 CC genotype in patients with DHF was compared to those with dengue fever (OR=1.9, p=0.034). Moreover, the presence of the CTLA-4 +49 G allele and TGFbeta1 -509 CC genotype increased the susceptibility to risk of DHF (OR=2.1, p=0.028) and significantly higher virus load (p=0.013). This finding suggests that a combination of CTLA-4 and TGFbeta1 polymorphisms is associated with the susceptibility of DHF and higher virus load.lld:pubmed
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pubmed-article:19269255pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:19269255pubmed:articleTitleCombination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak.lld:pubmed
pubmed-article:19269255pubmed:affiliationDepartment of Medical Research, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan.lld:pubmed
pubmed-article:19269255pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19269255pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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