Linked Life Data

19268478

Source:http://linkedlifedata.com/resource/pubmed/id/19268478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21-22
pubmed:dateCreated
2009-5-12
pubmed:abstractText
Phosphoenolpyruvate carboxykinase (PEPCK) is the rate limiting enzyme for gluconeogenesis, and plays a key role in recycling lactate for glucose production. It is synthesized as two separate isoforms; cytosolic (PEPCK-C, gene code; PCK1) and mitochondrial (PEPCK-M, gene code; PCK2). Previous studies of gluconeogenesis in endotoxemia have focused solely on PCK1. We investigated the relative roles of the two isoforms in hepatic and renal gluconeogenesis in a rat model of endotoxic shock, and in cultured hepatocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1879-0631
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
738-44
pubmed:meshHeading
pubmed-meshheading:19268478-Animals, pubmed-meshheading:19268478-Blood Pressure, pubmed-meshheading:19268478-Endotoxins, pubmed-meshheading:19268478-Glucose, pubmed-meshheading:19268478-Heart Rate, pubmed-meshheading:19268478-Hypoglycemia, pubmed-meshheading:19268478-Interleukin-1beta, pubmed-meshheading:19268478-Kidney, pubmed-meshheading:19268478-Lactates, pubmed-meshheading:19268478-Liver, pubmed-meshheading:19268478-Male, pubmed-meshheading:19268478-Mitochondria, pubmed-meshheading:19268478-Phosphoenolpyruvate Carboxykinase (GTP), pubmed-meshheading:19268478-RNA, Messenger, pubmed-meshheading:19268478-Rats, pubmed-meshheading:19268478-Rats, Wistar, pubmed-meshheading:19268478-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19268478-Subcellular Fractions, pubmed-meshheading:19268478-Tumor Necrosis Factor-alpha
pubmed:year
2009
pubmed:articleTitle
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
pubmed:affiliation
William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom. p.w.caton@qmul.ac.uk
pubmed:publicationType
Journal Article