Linked Life Data

19268424

Source:http://linkedlifedata.com/resource/pubmed/id/19268424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-6-8
pubmed:abstractText
The kinetic analysis by Kröger and Klingenberg on electron transfer in the Coenzyme Q region led to the conclusion that the quinone behaves kinetically as a homogeneous pool freely diffusing in the lipid bilayer, thus setting the basis for the widely accepted random diffusion model of electron transfer. The recent description of supramolecular complexes of the respiratory chain enzymes, in particular Complex I-III supercomplexes, has reopened the problem of electron transfer in the Coenzyme Q region. Flux control analysis has revealed that Complexes I and III indeed function as a single unit indicating substrate channelling by Coenzyme Q in transferring electrons from Complex I to Complex III. In this review we analyse in detail the reasons that suggested Coenzyme Q pool behaviour; although electron transfer between Complexes I and III indeed appears to be effected by substrate channelling, the Coenzyme Q pool is in equilibrium with bound quinone and is required to fill the site(s) within the supercomplex. In addition, the pool equation of Kröger and Klingenberg still describes in the most adequate way the electron transfer from Complex II and other Coenzyme Q-reducing enzymes to Complex III, besides the energy-dependent reverse electron transfer from Complex II to Complex I.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
1787
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
563-73
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Mobility and function of coenzyme Q (ubiquinone) in the mitochondrial respiratory chain.
pubmed:affiliation
Dipartimento di Biochimica G. Moruzzi, Università di Bologna, Via Irnerio 48, 40126 Bologna, Italy. giorgio.lenaz@unibo.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't