| pubmed-article:1926786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1926786 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:1926786 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:1926786 | lifeskim:mentions | umls-concept:C0302809 | lld:lifeskim |
| pubmed-article:1926786 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:1926786 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:1926786 | lifeskim:mentions | umls-concept:C0022341 | lld:lifeskim |
| pubmed-article:1926786 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1926786 | pubmed:dateCreated | 1991-11-21 | lld:pubmed |
| pubmed-article:1926786 | pubmed:abstractText | We studied the precore DNA sequences of hepatitis B viral genomes in five patients with fulminant hepatitis B and in five with acute self-limited hepatitis B from Japan. Using the polymerase chain reaction, three to four independent HBV DNA clones from each patient were obtained and analyzed. We demonstrated that patients with fulminant hepatitis B carried HBV genomes with a G to A mutation at nucleotide positions 1898 (five of five patients; 18 of 18 clones, 100%) and 1901 (five of five patients; 12 of 18 clones, 66%) in the precore region. The first mutation results in an in-phase stop codon (TAG) in the precore open reading frame and the absence of HBeAg production. In contrast, a G to A mutation was found in 6 of 16 clones (37%) in position 1898 and in 0 of 16 clones (0%) in position 1901 from patients with acute self-limited hepatitis. We concluded that both of the precore mutations are commonly associated with fulminant hepatitis B and may contribute to the pathogenesis of fulminant hepatitis. A hypothetical model for the biological significance of these two mutations is proposed. | lld:pubmed |
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| pubmed-article:1926786 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1926786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1926786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1926786 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1926786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1926786 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1926786 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:1926786 | pubmed:author | pubmed-author:HasegawaKK | lld:pubmed |
| pubmed-article:1926786 | pubmed:author | pubmed-author:ObataHH | lld:pubmed |
| pubmed-article:1926786 | pubmed:author | pubmed-author:WandsJ RJR | lld:pubmed |
| pubmed-article:1926786 | pubmed:author | pubmed-author:HuangJ KJK | lld:pubmed |
| pubmed-article:1926786 | pubmed:author | pubmed-author:LiangT JTJ | lld:pubmed |
| pubmed-article:1926786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1926786 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:1926786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1926786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1926786 | pubmed:pagination | 460-3 | lld:pubmed |
| pubmed-article:1926786 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1926786 | pubmed:meshHeading | pubmed-meshheading:1926786-... | lld:pubmed |
| pubmed-article:1926786 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1926786 | pubmed:articleTitle | Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan. | lld:pubmed |
| pubmed-article:1926786 | pubmed:affiliation | Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown 02129. | lld:pubmed |
| pubmed-article:1926786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1926786 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1926786 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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