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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-3-9
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pubmed:abstractText |
Priapism is defined as abnormal prolonged penile erection lasting at least for 4 hours occurring without sexual interest. Forty percent of sickle cell disease (SCD) patients display priapism. The disorder is dangerous and urgent given its association with ischemia-mediated erectile tissue damage and subsequent erectile dysfunction. Current strategies to manage the disorder are poor due to lack of fundamental understanding of the molecular mechanisms of priapism. Adenosine is a signaling nucleoside that elicits many pathophysiological effects by engaging membrane receptors. Recent evidence shows that adenosine may play an important role in priapism via adenosine receptor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1743-6109
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6 Suppl 3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
292-301
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19267852-Adenosine,
pubmed-meshheading:19267852-Adenosine Deaminase,
pubmed-meshheading:19267852-Animals,
pubmed-meshheading:19267852-Endothelium, Vascular,
pubmed-meshheading:19267852-Fibrosis,
pubmed-meshheading:19267852-Male,
pubmed-meshheading:19267852-Mice,
pubmed-meshheading:19267852-Muscle, Smooth,
pubmed-meshheading:19267852-Penis,
pubmed-meshheading:19267852-Phosphodiesterase 5 Inhibitors,
pubmed-meshheading:19267852-Phosphodiesterase Inhibitors,
pubmed-meshheading:19267852-Priapism,
pubmed-meshheading:19267852-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Adenosine signaling, priapism and novel therapies.
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pubmed:affiliation |
University of Texas at Houston Medical School, Biochemistry and Molecular Biology, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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