Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-11-18
|
| pubmed:abstractText |
The receptor protein solubilized from synaptic membranes specifically binds [14C] NAD (dissociation constant--0.75 microM, capacity of binding sites--0.0125 nmol of metaid per 1 mg of protein). All the studied benzodiazepines (phenazepam, nitrazepam, clonazepam, flunitrazepam) are able to displace [14C] NAD from its receptor sites, the mixed type of inhibition being manifested. An inhibition constant for flunitrazepam, a ligand of benzodiazepine receptors, equals 10 microM. GABA promotes an inhibiting effect of benzodiazepines. It is supposed that neurotropic action of NAD is realized through the GABA-benzodiazepine complex of neuronal membranes.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0201-8470
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
65-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:1926588-Animals,
pubmed-meshheading:1926588-Benzodiazepines,
pubmed-meshheading:1926588-Binding Sites,
pubmed-meshheading:1926588-Brain,
pubmed-meshheading:1926588-Male,
pubmed-meshheading:1926588-Membrane Proteins,
pubmed-meshheading:1926588-NAD,
pubmed-meshheading:1926588-Rats,
pubmed-meshheading:1926588-Synaptic Membranes
|
| pubmed:articleTitle |
[Effect of benzodiazepines on NAD binding to synaptic membrane in the rat brain].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|