Source:http://linkedlifedata.com/resource/pubmed/id/19265135
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2009-3-6
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| pubmed:abstractText |
Distinct Notch ligands possess a characteristic ability in terms of functional T cell differentiation. However, the precise role or the therapeutic potential of each Notch ligand in autoimmune diseases is largely unknown. In this study, we examined whether Jagged1 modulates a collagen-induced rheumatoid arthritis (CIA) model by altering T cell responses. The injection of a soluble Jagged1-encoding plasmid, sJag1-P, before or even after initial type II collagen (CII) immunization suppressed the disease severity of CIA. However, this treatment did not suppress CII-specific CD4(+) T cell proliferation and CII-specific Ab production. Depletion of either CD4(+) or CD8(+) T cells ameliorated CIA severity and sJag1-P further improved CIA in CD4(+) but not CD8(+) T cell-depleted mice. Injection of OVA and Jagged1-encoding plasmids inhibited proliferation of OVA-specific granzyme B-producing CD8(+) T cells, although Jagged1 could not directly inhibit CD8(+) T cell proliferation in vitro. The blockade of Jagged1 by an anti-Jagged1 Ab exacerbated CIA, whereas this effect was not observed in the absence of CD8(+) T cells. These data indicate that Jagged1 is able to deliver an indirect negative signal into CD8(+) T cells in vivo, which suggests its therapeutic potential in the treatment of CD8(+) T cell-mediated diseases, including rheumatoid arthritis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serrate proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
182
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3566-72
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| pubmed:meshHeading |
pubmed-meshheading:19265135-Animals,
pubmed-meshheading:19265135-Arthritis, Experimental,
pubmed-meshheading:19265135-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19265135-Calcium-Binding Proteins,
pubmed-meshheading:19265135-Cell Line,
pubmed-meshheading:19265135-Cells, Cultured,
pubmed-meshheading:19265135-Down-Regulation,
pubmed-meshheading:19265135-Growth Inhibitors,
pubmed-meshheading:19265135-Humans,
pubmed-meshheading:19265135-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19265135-Jurkat Cells,
pubmed-meshheading:19265135-Lymphocyte Activation,
pubmed-meshheading:19265135-Lymphocyte Depletion,
pubmed-meshheading:19265135-Male,
pubmed-meshheading:19265135-Membrane Proteins,
pubmed-meshheading:19265135-Mice,
pubmed-meshheading:19265135-Mice, Inbred C57BL,
pubmed-meshheading:19265135-Mice, Inbred DBA,
pubmed-meshheading:19265135-Plasmids,
pubmed-meshheading:19265135-Signal Transduction,
pubmed-meshheading:19265135-Vaccines, DNA
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| pubmed:year |
2009
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| pubmed:articleTitle |
Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.
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| pubmed:affiliation |
Department of Immunology and Parasitology, University of Tokushima Graduate School, Tokushima, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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