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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-4-3
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pubmed:abstractText |
The present study aimed to evaluate whether levels of urinary L-type fatty acid-binding protein (L-FABP) could be used to monitor histological injury in acute kidney injury (AKI) induced by cis-platinum (CP) injection and ischemia reperfusion (IR). Different degrees of AKI severity were induced by several renal insults (CP dose and ischemia time) in human L-FABP transgenic mice. Renal histological injury scores increased with both CP dose and ischemic time. In CP-induced AKI, urinary L-FABP levels increased exponentially even in the lowest dose group as early as 2 hours, whereas blood urea nitrogen (BUN) levels increased at 48 hours. In IR-induced AKI, BUN levels increased only in the 30-minute ischemia group 24 hours after reperfusion; however, urinary L-FABP levels increased more than 100-fold, even in the 5-minute ischemia group after 1 hour. In both AKI models, urinary L-FABP levels showed a better correlation with final histological injury scores and glomerular filtration rates measured by fluorescein isothiocyanate-labeled inulin injection than with levels of BUN and urinary N-acetyl-D-glucosaminidase, especially at earlier time points. Receiver operating characteristic curve analysis demonstrated that urinary L-FABP was superior to other biomarkers for the detection of significant histological injuries and functional declines. In conclusion, urinary L-FABP levels are better suited to allow the accurate and earlier detection of both histological and functional insults in ischemic and nephrotoxin-induced AKI compared with conventional renal markers.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-12081583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-15086910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-15213255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-15811456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-16148039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-16177006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-16543755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-16710348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-16931980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-17331245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-17678545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-17942962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18059454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18094679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18094680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18272962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18368030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18633340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-18650797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-2981404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19264903-8636419
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1525-2191
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1154-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19264903-Animals,
pubmed-meshheading:19264903-Biological Markers,
pubmed-meshheading:19264903-Cisplatin,
pubmed-meshheading:19264903-Cross-Linking Reagents,
pubmed-meshheading:19264903-Dose-Response Relationship, Drug,
pubmed-meshheading:19264903-Fatty Acid-Binding Proteins,
pubmed-meshheading:19264903-Humans,
pubmed-meshheading:19264903-Kidney,
pubmed-meshheading:19264903-Kidney Diseases,
pubmed-meshheading:19264903-Kidney Function Tests,
pubmed-meshheading:19264903-Male,
pubmed-meshheading:19264903-Mice,
pubmed-meshheading:19264903-Mice, Transgenic,
pubmed-meshheading:19264903-ROC Curve,
pubmed-meshheading:19264903-Reperfusion Injury
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pubmed:year |
2009
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pubmed:articleTitle |
Monitoring of urinary L-type fatty acid-binding protein predicts histological severity of acute kidney injury.
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pubmed:affiliation |
Department of Nephrology and Endocrinology, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan 113-8655.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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