| pubmed-article:19264842 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19264842 | lifeskim:mentions | umls-concept:C0010853 | lld:lifeskim |
| pubmed-article:19264842 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:19264842 | lifeskim:mentions | umls-concept:C1419227 | lld:lifeskim |
| pubmed-article:19264842 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19264842 | pubmed:dateCreated | 2009-5-27 | lld:pubmed |
| pubmed-article:19264842 | pubmed:abstractText | It is well established that epidermal growth factor (EGF) induces the cytoskeleton reorganization and cell migration through two major signaling cascades: phospholipase C-gamma1 (PLC-gamma1) and Rho GTPases. However, little is known about the cross talk between PLC-gamma1 and Rho GTPases. Here we showed that PLC-gamma1 forms a complex with Rac1 in response to EGF. This interaction is direct and mediated by PLC-gamma1 Src homology 3 (SH3) domain and Rac1 (106)PNTP(109) motif. This interaction is critical for EGF-induced Rac1 activation in vivo, and PLC-gamma1 SH3 domain is actually a potent and specific Rac1 guanine nucleotide exchange factor in vitro. We have also demonstrated that the interaction between PLC-gamma1 SH3 domain and Rac1 play a significant role in EGF-induced F-actin formation and cell migration. We conclude that PLC-gamma1 and Rac1 coregulate EGF-induced cell cytoskeleton remodeling and cell migration by a direct functional interaction. | lld:pubmed |
| pubmed-article:19264842 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19264842 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264842 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19264842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264842 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19264842 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19264842 | pubmed:issn | 1944-9917 | lld:pubmed |
| pubmed-article:19264842 | pubmed:author | pubmed-author:WangYiY | lld:pubmed |
| pubmed-article:19264842 | pubmed:author | pubmed-author:WangQianQ | lld:pubmed |
| pubmed-article:19264842 | pubmed:author | pubmed-author:ChenXinmeiX | lld:pubmed |
| pubmed-article:19264842 | pubmed:author | pubmed-author:WangZhixiangZ | lld:pubmed |
| pubmed-article:19264842 | pubmed:author | pubmed-author:LiSiweiS | lld:pubmed |
| pubmed-article:19264842 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19264842 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:19264842 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19264842 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19264842 | pubmed:pagination | 901-13 | lld:pubmed |
| pubmed-article:19264842 | pubmed:meshHeading | pubmed-meshheading:19264842... | lld:pubmed |
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| pubmed-article:19264842 | pubmed:meshHeading | pubmed-meshheading:19264842... | lld:pubmed |
| pubmed-article:19264842 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19264842 | pubmed:articleTitle | PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration. | lld:pubmed |
| pubmed-article:19264842 | pubmed:affiliation | Department of Cell Biology, University of Alberta, Edmonton, Canada. | lld:pubmed |
| pubmed-article:19264842 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19264842 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
