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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-5
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pubmed:abstractText |
Change in cognitive function in response to a pharmacologic challenge can be observed with greater sensitivity by employing cognitive tests with optimal psychometric properties and a statistical approach that more accurately accounts for individual variability in performance. To demonstrate this approach we examined the cognitive effects of a single acute dose administration of an acetylcholinesterase inhibitor, donepezil, in healthy older adults and in older adults with mild Alzheimer's disease (AD).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1279-7707
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
268-73
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pubmed:meshHeading |
pubmed-meshheading:19262966-Aged,
pubmed-meshheading:19262966-Alzheimer Disease,
pubmed-meshheading:19262966-Cholinesterase Inhibitors,
pubmed-meshheading:19262966-Cognition,
pubmed-meshheading:19262966-Cognition Disorders,
pubmed-meshheading:19262966-Cross-Over Studies,
pubmed-meshheading:19262966-Double-Blind Method,
pubmed-meshheading:19262966-Humans,
pubmed-meshheading:19262966-Indans,
pubmed-meshheading:19262966-Male,
pubmed-meshheading:19262966-Maze Learning,
pubmed-meshheading:19262966-Memory, Short-Term,
pubmed-meshheading:19262966-Middle Aged,
pubmed-meshheading:19262966-Neuropsychological Tests,
pubmed-meshheading:19262966-Piperidines,
pubmed-meshheading:19262966-Psychometrics,
pubmed-meshheading:19262966-Reproducibility of Results,
pubmed-meshheading:19262966-Research Design,
pubmed-meshheading:19262966-Sensitivity and Specificity
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pubmed:year |
2009
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pubmed:articleTitle |
Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil.
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pubmed:affiliation |
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial, Phase I
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