Source:http://linkedlifedata.com/resource/pubmed/id/19262476
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2009-3-5
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| pubmed:abstractText |
Resistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1348-4214
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| pubmed:author |
pubmed-author:CoeliFernanda BFB,
pubmed-author:FaveroFabrício FFF,
pubmed-author:Izidoro-ToledoTatiane CTC,
pubmed-author:LacchiniRiccardoR,
pubmed-author:MorenoHeitorHJr,
pubmed-author:SabhaMariceneM,
pubmed-author:SandrimValéria CVC,
pubmed-author:Tanus-SantosJosé EJE,
pubmed-author:Yugar-ToledoJuanJ,
pubmed-author:de MelloMaricilda PMP
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| pubmed:issnType |
Electronic
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| pubmed:volume |
32
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
159-62
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| pubmed:meshHeading |
pubmed-meshheading:19262476-Adult,
pubmed-meshheading:19262476-Aldosterone,
pubmed-meshheading:19262476-Aldosterone Synthase,
pubmed-meshheading:19262476-Alleles,
pubmed-meshheading:19262476-Blood Pressure,
pubmed-meshheading:19262476-Carotid Arteries,
pubmed-meshheading:19262476-Drug Resistance,
pubmed-meshheading:19262476-Female,
pubmed-meshheading:19262476-Gene Frequency,
pubmed-meshheading:19262476-Genotype,
pubmed-meshheading:19262476-Humans,
pubmed-meshheading:19262476-Hydrocortisone,
pubmed-meshheading:19262476-Hypertension,
pubmed-meshheading:19262476-Male,
pubmed-meshheading:19262476-Middle Aged,
pubmed-meshheading:19262476-Polymorphism, Genetic,
pubmed-meshheading:19262476-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19262476-Renin
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| pubmed:year |
2009
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| pubmed:articleTitle |
T allele of -344 C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension.
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| pubmed:affiliation |
Cardiovascular Pharmacology Laboratory, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. lacchi_4@terra.com.br
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|