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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-5
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pubmed:abstractText |
We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (< or =500 microM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 muM significantly inhibited cancer cell migration without effecting non-tumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at eight days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-10050909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-10050921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-10050927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-10076586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-10805515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-10906539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-11550073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-12044035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-12481254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-12647314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-12806432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-14713551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-15010890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-15170447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-15500945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-15728385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-16207680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-16495920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-16842198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-16883056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-16892035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-17086301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-17186423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-17409287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-17652276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-18045731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-18080240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-18158980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-2447614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-3370093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-3746985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-6595986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-6606682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-6732506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-7760101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-7889870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-7889881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-7908243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-7916160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-9706231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19262119-9877029
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1933-6926
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-60
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pubmed:dateRevised |
2010-12-7
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pubmed:meshHeading |
pubmed-meshheading:19262119-Boric Acids,
pubmed-meshheading:19262119-Boronic Acids,
pubmed-meshheading:19262119-Breast Neoplasms,
pubmed-meshheading:19262119-Cell Adhesion,
pubmed-meshheading:19262119-Cell Line, Tumor,
pubmed-meshheading:19262119-Cell Movement,
pubmed-meshheading:19262119-Cell Survival,
pubmed-meshheading:19262119-Fibronectins,
pubmed-meshheading:19262119-Humans,
pubmed-meshheading:19262119-Male,
pubmed-meshheading:19262119-Prostatic Neoplasms,
pubmed-meshheading:19262119-Time Factors
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pubmed:articleTitle |
Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability.
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pubmed:affiliation |
Department of Biology, Rensselaer Polytechnic Institute, Troy, New York 12180-3596, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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