|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2009-8-11
|
|
pubmed:abstractText |
Intrahepatic cholestasis of pregnancy is a liver disorder with a multifactorial etiology characterized by maternal pruritus, abnormal liver function tests and increased fetal risk. The main biochemical finding is the increase in total serum bile acid concentrations. In a subgroup of women, the serum gamma-glutamyl transpeptidase level is also increased. There is evidence that dysfunction of the ABCB4 gene might play a role in intrahepatic cholestasis of pregnancy development.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1878-3562
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
41
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
671-5
|
|
pubmed:meshHeading |
pubmed-meshheading:19261551-Adult,
pubmed-meshheading:19261551-Bile Acids and Salts,
pubmed-meshheading:19261551-Cholestasis, Intrahepatic,
pubmed-meshheading:19261551-DNA Mutational Analysis,
pubmed-meshheading:19261551-Female,
pubmed-meshheading:19261551-Humans,
pubmed-meshheading:19261551-P-Glycoproteins,
pubmed-meshheading:19261551-Pregnancy,
pubmed-meshheading:19261551-Pregnancy Complications,
pubmed-meshheading:19261551-Promoter Regions, Genetic,
pubmed-meshheading:19261551-Protein Splicing,
pubmed-meshheading:19261551-Pruritus,
pubmed-meshheading:19261551-gamma-Glutamyltransferase
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT.
|
|
pubmed:affiliation |
Laboratory of Human Molecular Biology and Genetics, Catholic University of the Sacred Heart, Milan, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
