Linked Life Data

19257794

Source:http://linkedlifedata.com/resource/pubmed/id/19257794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-3-4
pubmed:abstractText
The Gaussian network model is used to derive the correlations between energy and residue fluctuations in native proteins. Residues are identified that respond strongly to energy fluctuations and that display correlations with the remaining residues of the protein at the highest modes. We postulate that these residues are located at specific sites for drug binding. We test the validity of this postulate on a data set of 33 structurally distinct proteins in the unbound state. Detailed results are presented for drug binding to the HIV protease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0031-9007
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
088103
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Analysis of correlations between energy and residue fluctuations in native proteins and determination of specific sites for binding.
pubmed:affiliation
Polymer Research Center, Bogazici University, Bebek, Istanbul, Turkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't