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pubmed-article:19255727pubmed:abstractTextThe effectiveness of vaccines depends on the age and immunocompetence of the vaccinee. Conventional non-adjuvanted influenza vaccines are suboptimal in the elderly and vaccines with improved ability to prevent influenza are required. The TLR4 agonist E6020, either given alone or co-delivered with MF59, was evaluated and compared to MF59 and the TLR9 agonist CpG. Its ability to enhance antibody titres and to modulate the quality of the immune response to a subunit influenza vaccine was investigated.lld:pubmed
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pubmed-article:19255727pubmed:articleTitleMF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).lld:pubmed
pubmed-article:19255727pubmed:affiliationNovartis Vaccines, Via Fiorentina 1, Siena, Italy. barbara.baudner@novartis.comlld:pubmed
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