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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-6
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pubmed:abstractText |
The effectiveness of vaccines depends on the age and immunocompetence of the vaccinee. Conventional non-adjuvanted influenza vaccines are suboptimal in the elderly and vaccines with improved ability to prevent influenza are required. The TLR4 agonist E6020, either given alone or co-delivered with MF59, was evaluated and compared to MF59 and the TLR9 agonist CpG. Its ability to enhance antibody titres and to modulate the quality of the immune response to a subunit influenza vaccine was investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/MF59 oil emulsion,
http://linkedlifedata.com/resource/pubmed/chemical/Polysorbates,
http://linkedlifedata.com/resource/pubmed/chemical/Squalene,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1573-904X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1477-85
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pubmed:meshHeading |
pubmed-meshheading:19255727-Adjuvants, Immunologic,
pubmed-meshheading:19255727-Animals,
pubmed-meshheading:19255727-Antibodies, Viral,
pubmed-meshheading:19255727-Cytokines,
pubmed-meshheading:19255727-Drug Delivery Systems,
pubmed-meshheading:19255727-Female,
pubmed-meshheading:19255727-Hemagglutination Inhibition Tests,
pubmed-meshheading:19255727-Immunization,
pubmed-meshheading:19255727-Immunoglobulin G,
pubmed-meshheading:19255727-Influenza A Virus, H1N1 Subtype,
pubmed-meshheading:19255727-Influenza A Virus, H3N2 Subtype,
pubmed-meshheading:19255727-Influenza Vaccines,
pubmed-meshheading:19255727-Mice,
pubmed-meshheading:19255727-Mice, Inbred BALB C,
pubmed-meshheading:19255727-Polysorbates,
pubmed-meshheading:19255727-Squalene,
pubmed-meshheading:19255727-Th1 Cells,
pubmed-meshheading:19255727-Th2 Cells,
pubmed-meshheading:19255727-Toll-Like Receptor 4
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pubmed:year |
2009
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pubmed:articleTitle |
MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).
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pubmed:affiliation |
Novartis Vaccines, Via Fiorentina 1, Siena, Italy. barbara.baudner@novartis.com
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pubmed:publicationType |
Journal Article
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