Source:http://linkedlifedata.com/resource/pubmed/id/19255265
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2009-3-3
|
| pubmed:abstractText |
Skin rash associated with nevirapine (NVP) is common and efavirenz (EFV) is often used as a substitute. We aimed to determine the predicting factors for unsuccessful switching from NVP to EFV. A retrospective cohort study was conducted in HIV-infected patients who developed rash after taking NVP. There were 109 patients with a mean standard deviation (SD) age of 36.6 (7.4) years and 45% were males. Median (interquartile range) CD4 cell count and HIV RNA at the time of NVP initiation were 163 (50-273) cells/mm(3) and 4.6 (1.7-5.4) log copies/mL, respectively. Twenty (18.3%) patients subsequently developed EFV-associated rash. By logistic regression, history of drug allergy apart from NVP (odds ratio [OR] 11.42) and CD4 cell count <100 cells/mm(3) (OR 6.14) were significant predicting factors for EFV-associated rash. Two predicting factors for unsuccessful switching from NVP to EFV were found. Patients who have these factors need to have a close follow-up if EFV is substituted.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0956-4624
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
176-9
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| pubmed:meshHeading |
pubmed-meshheading:19255265-Adult,
pubmed-meshheading:19255265-Anti-HIV Agents,
pubmed-meshheading:19255265-Benzoxazines,
pubmed-meshheading:19255265-CD4 Lymphocyte Count,
pubmed-meshheading:19255265-Chi-Square Distribution,
pubmed-meshheading:19255265-Cohort Studies,
pubmed-meshheading:19255265-Drug Hypersensitivity,
pubmed-meshheading:19255265-Exanthema,
pubmed-meshheading:19255265-Female,
pubmed-meshheading:19255265-HIV Infections,
pubmed-meshheading:19255265-Humans,
pubmed-meshheading:19255265-Logistic Models,
pubmed-meshheading:19255265-Male,
pubmed-meshheading:19255265-Nevirapine,
pubmed-meshheading:19255265-Retrospective Studies,
pubmed-meshheading:19255265-Risk Factors,
pubmed-meshheading:19255265-Statistics, Nonparametric,
pubmed-meshheading:19255265-Viral Load
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Predicting factors for unsuccessful switching from nevirapine to efavirenz in HIV-infected patients who developed nevirapine-associated skin rash.
|
| pubmed:affiliation |
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok 10400, Thailand. rasal@mahidol.ac.th
|
| pubmed:publicationType |
Journal Article
|