| pubmed-article:19254843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19254843 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:19254843 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19254843 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19254843 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19254843 | lifeskim:mentions | umls-concept:C1516155 | lld:lifeskim |
| pubmed-article:19254843 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19254843 | pubmed:dateCreated | 2009-3-16 | lld:pubmed |
| pubmed-article:19254843 | pubmed:abstractText | Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of the topoisomerase I (Topo I)/DNA/camptothecin ternary complex. The analogs were prepared from 9-nitrocamptothecin via 7,9-diaminocamptothecin derivatives as a key intermediate. Among them, 7c exhibited in vivo antitumor activities superior to CPT-11 in human cancer xenograft models in mice at their maximum tolerated doses though its in vitro antiproliferative activity was comparable to SN-38 against corresponding cell lines. | lld:pubmed |
| pubmed-article:19254843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19254843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19254843 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19254843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19254843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19254843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19254843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19254843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19254843 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19254843 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:NiizumaSatosh... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:FukudaHiroshi... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:MorikamiKenji... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:ShimmaNobuoN | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:KawashimaAkir... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:KobayashiKazu... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:TakasukaTsuyo... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:OhwadaJunJ | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:MurasakiChika... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:UmedaIsaoI | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:MurataTakeshi... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:TsukazakiMasa... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:SudaHitomiH | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:UraMasakoM | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:TanimuraHirom... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:OkabeHisafumi... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:EndoMikaM | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:OgawaKotaroK | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:NakanoKounosu... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:YoshinariKiyo... | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:MiyazakiYokoY | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:KohchiMasamiM | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:OzawaSawakoS | lld:pubmed |
| pubmed-article:19254843 | pubmed:author | pubmed-author:NanbaEitaroE | lld:pubmed |
| pubmed-article:19254843 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19254843 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19254843 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19254843 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19254843 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19254843 | pubmed:pagination | 2018-21 | lld:pubmed |
| pubmed-article:19254843 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:meshHeading | pubmed-meshheading:19254843... | lld:pubmed |
| pubmed-article:19254843 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19254843 | pubmed:articleTitle | Synthesis of new camptothecin analogs with improved antitumor activities. | lld:pubmed |
| pubmed-article:19254843 | pubmed:affiliation | Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan. | lld:pubmed |
| pubmed-article:19254843 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19254843 | lld:chembl |
