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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-3-16
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pubmed:abstractText |
Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of the topoisomerase I (Topo I)/DNA/camptothecin ternary complex. The analogs were prepared from 9-nitrocamptothecin via 7,9-diaminocamptothecin derivatives as a key intermediate. Among them, 7c exhibited in vivo antitumor activities superior to CPT-11 in human cancer xenograft models in mice at their maximum tolerated doses though its in vitro antiproliferative activity was comparable to SN-38 against corresponding cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:EndoMikaM,
pubmed-author:FukudaHiroshiH,
pubmed-author:KawashimaAkiraA,
pubmed-author:KobayashiKazukoK,
pubmed-author:KohchiMasamiM,
pubmed-author:MiyazakiYokoY,
pubmed-author:MorikamiKenjiK,
pubmed-author:MurasakiChikakoC,
pubmed-author:MurataTakeshiT,
pubmed-author:NakanoKounosukeK,
pubmed-author:NanbaEitaroE,
pubmed-author:NiizumaSatoshiS,
pubmed-author:OgawaKotaroK,
pubmed-author:OhwadaJunJ,
pubmed-author:OkabeHisafumiH,
pubmed-author:OzawaSawakoS,
pubmed-author:ShimmaNobuoN,
pubmed-author:SudaHitomiH,
pubmed-author:TakasukaTsuyoshiT,
pubmed-author:TanimuraHiromiH,
pubmed-author:TsukazakiMasaoM,
pubmed-author:UmedaIsaoI,
pubmed-author:UraMasakoM,
pubmed-author:YoshinariKiyoshiK
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2018-21
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19254843-Animals,
pubmed-meshheading:19254843-Antineoplastic Agents,
pubmed-meshheading:19254843-Camptothecin,
pubmed-meshheading:19254843-Cell Line, Tumor,
pubmed-meshheading:19254843-DNA Topoisomerases, Type I,
pubmed-meshheading:19254843-Humans,
pubmed-meshheading:19254843-Mice,
pubmed-meshheading:19254843-Structure-Activity Relationship,
pubmed-meshheading:19254843-Topoisomerase I Inhibitors,
pubmed-meshheading:19254843-Transplantation, Heterologous
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis of new camptothecin analogs with improved antitumor activities.
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pubmed:affiliation |
Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
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pubmed:publicationType |
Journal Article
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