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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-4-15
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pubmed:abstractText |
Orthostatic hypotension has been observed when PDE 5 (cGMP-specific phosphodiesterase type 5) inhibitors are co-administered with alpha-adrenoceptor antagonists. Here we assessed the pharmacokinetic and haemodynamic interactions between udenafil and tamsulosin in rats, as both drugs are metabolized via rat hepatic cytochrome P450 3A1/2.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-11512128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-13093635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-14603504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-15540759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-15618743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-15801542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-15828055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-15886285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-15979430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-16937336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-17351661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-17958337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-18204480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-18318773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-18697186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-240655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-731416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-8730926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-9344174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19254278-9849639
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyp3a1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyp3a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase 5 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/tamsulosin,
http://linkedlifedata.com/resource/pubmed/chemical/udenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1009-18
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19254278-Administration, Oral,
pubmed-meshheading:19254278-Adrenergic alpha-Antagonists,
pubmed-meshheading:19254278-Animals,
pubmed-meshheading:19254278-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19254278-Blood Pressure,
pubmed-meshheading:19254278-Cytochrome P-450 CYP3A,
pubmed-meshheading:19254278-Drug Antagonism,
pubmed-meshheading:19254278-Humans,
pubmed-meshheading:19254278-Infusions, Intravenous,
pubmed-meshheading:19254278-Liver,
pubmed-meshheading:19254278-Male,
pubmed-meshheading:19254278-Membrane Proteins,
pubmed-meshheading:19254278-Microsomes, Liver,
pubmed-meshheading:19254278-Phosphodiesterase 5 Inhibitors,
pubmed-meshheading:19254278-Pyrimidines,
pubmed-meshheading:19254278-Rats,
pubmed-meshheading:19254278-Rats, Sprague-Dawley,
pubmed-meshheading:19254278-Sulfonamides
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pubmed:year |
2009
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pubmed:articleTitle |
Interaction between udenafil and tamsulosin in rats: non-competitive inhibition of tamsulosin metabolism by udenafil via hepatic CYP3A1/2.
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pubmed:affiliation |
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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