Linked Life Data

19253409

Source:http://linkedlifedata.com/resource/pubmed/id/19253409

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-8-27
pubmed:abstractText
Lens of vertebrate eyes is derived from competent pre-placodal ectoderm in response to signal(s) from retinal lineage. We herein report that the Xenopus Hes gene Xhairy2, which is expressed in pre-placodal ectoderm, is required for lens development from the initial stage. We show that Xhairy2 knockdown reduced the expression of lens marker genes at every step of lens determination, eventually resulting in ocular lens malformation. Interestingly, retina marker gene expression and retinal anlage morphology remained normal upon Xhairy2 knockdown. Furthermore, loss of lens field caused by Xhairy2 depletion was partially rescued by simultaneous knockdown of the cell cycle inhibitor gene p27(xic1). These results suggest that Xhairy2 is required for lens development through the regulation of p27(xic1) expression, independent of the known cascade of transcription factors. Based on these findings, we propose that Xhairy2 may maintain an intracellular environment in which inducing signal(s) can be accepted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1097-0177
pubmed:author
pubmed:copyrightInfo
2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
238
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2179-92
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Xhairy2 functions in Xenopus lens development by regulating p27(xic1) expression.
pubmed:affiliation
Department of Biology, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka, Japan.
pubmed:publicationType
Journal Article