Source:http://linkedlifedata.com/resource/pubmed/id/19252761
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2009-4-28
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| pubmed:abstractText |
The aim of our study was to investigate the sex- and age-related changes of serum Dickkopf-1 (Dkk-1), a soluble inhibitor of the Wnt signaling pathway, in healthy individuals and in patients with breast cancer (BC) and bone metastases (BM) using a new ELISA. Association of serum Dkk-1 with markers of bone turnover was also investigated. Serum Dkk-1 measurements were performed using a commercial sandwich ELISA in 150 healthy men, 175 healthy pre- and postmenopausal women (20-65 years), 22 women with BC and BM (mean age 63 years), and 16 women with BC and metastases at sites other than bone (mean age 53 years). Intra- and interassay coefficients of variation were below 7% and 12%, respectively. The detection limit was determined to be 0.018 microg/L. In healthy women and men, Dkk-1 did not change with age. Serum Dkk-1 modestly correlated with serum bone alkaline phosphatase (r = 0.19, P = 0.013) and serum C-terminal cross-linking telopeptide of type I collagen (r = 0.19, P = 0.014) in women but not in men. Dkk-1 levels were higher in women with BC and BM (5.57 +/- 5.50 microg/L) than in healthy age-matched controls (3.47 +/- 1.47 microg/L, P < 0.0001) and women with metastases at sites other than bone (3.57 +/- 1.66 microg/L, P = 0.0003). In conclusion, serum Dkk-1 is stable with age in healthy women and men and increases in patients with BC and BM. Measurements of circulating Dkk-1 with this new ELISA may be useful for the clinical investigation of patients with malignant bone diseases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/DKK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1432-0827
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
84
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
348-54
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| pubmed:meshHeading |
pubmed-meshheading:19252761-Adult,
pubmed-meshheading:19252761-Aged,
pubmed-meshheading:19252761-Aging,
pubmed-meshheading:19252761-Alkaline Phosphatase,
pubmed-meshheading:19252761-Bone Neoplasms,
pubmed-meshheading:19252761-Bone and Bones,
pubmed-meshheading:19252761-Breast Neoplasms,
pubmed-meshheading:19252761-Carcinoma,
pubmed-meshheading:19252761-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19252761-Female,
pubmed-meshheading:19252761-Humans,
pubmed-meshheading:19252761-Immunoassay,
pubmed-meshheading:19252761-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19252761-Male,
pubmed-meshheading:19252761-Middle Aged,
pubmed-meshheading:19252761-Predictive Value of Tests,
pubmed-meshheading:19252761-Signal Transduction,
pubmed-meshheading:19252761-Tumor Markers, Biological,
pubmed-meshheading:19252761-Up-Regulation,
pubmed-meshheading:19252761-Wnt Proteins,
pubmed-meshheading:19252761-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Assessment of circulating Dickkopf-1 with a new two-site immunoassay in healthy subjects and women with breast cancer and bone metastases.
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| pubmed:affiliation |
Biochemical Markers, Synarc, Lyon, France.
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| pubmed:publicationType |
Journal Article
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