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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
7
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pubmed:dateCreated |
2009-3-16
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pubmed:abstractText |
A novel series of semi-synthetic trioxaquines and synthetic trioxolaquines were prepared, in moderate to good yields. Antimalarial activity was evaluated against both the chloroquine-sensitive 3D7 and resistant K1 strain of Plasmodium falciparum and both series of compounds were shown to be active in the low nanomolar range. For comparison the corresponding 9-amino acridine analogues were also prepared and shown to have low nanomolar activity like their quinoline counterparts.
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pubmed:grant |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
|
|
pubmed:issn |
1464-3405
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
1
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2038-43
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pubmed:meshHeading |
|
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pubmed:year |
2009
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|
pubmed:articleTitle |
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.
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|
pubmed:affiliation |
Centro de Ciências do Mar and Departamento de Química e Bioquímica, F.C.T, Campus de Gambelas, Universidade do Algarve, 8005-039 Faro, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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