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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
Patients carrying loss-of-function SCN5A mutations linked to Brugada syndrome (BrS) or progressive cardiac conduction disease (PCCD) are at risk of sudden cardiac death at a young age. The penetrance and expressivity of the disease are highly variable, and new tools for risk stratification are needed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1556-3871
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pubmed:author |
pubmed-author:AlbuissonJJ,
pubmed-author:BezzinaConnie RCR,
pubmed-author:BhuiyanZahurul AZA,
pubmed-author:KoopmannTamara TTT,
pubmed-author:KyndtFlorenceF,
pubmed-author:Le MarecHerveH,
pubmed-author:MaboPhilippeP,
pubmed-author:MeregalliPaola GPG,
pubmed-author:ProbstVincentV,
pubmed-author:SacherFredericF,
pubmed-author:SchottJean-JacquesJJ,
pubmed-author:TanHanno LHL,
pubmed-author:TanckMichael WMW,
pubmed-author:WildeArthur A MAA
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-8
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:19251209-Adult,
pubmed-meshheading:19251209-Arrhythmias, Cardiac,
pubmed-meshheading:19251209-Brugada Syndrome,
pubmed-meshheading:19251209-Codon, Terminator,
pubmed-meshheading:19251209-Death, Sudden, Cardiac,
pubmed-meshheading:19251209-Female,
pubmed-meshheading:19251209-Heart Conduction System,
pubmed-meshheading:19251209-Humans,
pubmed-meshheading:19251209-Male,
pubmed-meshheading:19251209-Middle Aged,
pubmed-meshheading:19251209-Muscle Proteins,
pubmed-meshheading:19251209-Mutation,
pubmed-meshheading:19251209-Mutation, Missense,
pubmed-meshheading:19251209-Phenotype,
pubmed-meshheading:19251209-Risk Assessment,
pubmed-meshheading:19251209-Sodium Channel Blockers,
pubmed-meshheading:19251209-Sodium Channels
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pubmed:year |
2009
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pubmed:articleTitle |
Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies.
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pubmed:affiliation |
Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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