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rdf:type |
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lifeskim:mentions |
umls-concept:C0017636,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0027651,
umls-concept:C0242184,
umls-concept:C0442797,
umls-concept:C0522537,
umls-concept:C1414352,
umls-concept:C1522449,
umls-concept:C1704410,
umls-concept:C1822997
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
Eukaryotic initiation factor 4E (eIF4E) is an essential rate-limiting factor for cap-dependent translation in eukaryotic cells. Elevated eIF4E activity is common in many human tumors and is associated with disease progression. The growth-promoting effects of eIF4E are in turn negatively regulated by 4E-BP1. However, although 4E-BP1 harbors anti-growth activity, its expression is paradoxically elevated in some tumors. The aim of this study was to investigate the functional role of 4E-BP1 in the context of solid tumors.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1879-355X
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pubmed:author |
pubmed-author:ClevenArjen H GAH,
pubmed-author:DuboisLudwigL,
pubmed-author:GorrThomas ATA,
pubmed-author:GrenacherBeatB,
pubmed-author:KoritzinskyMarianneM,
pubmed-author:LambinPhilippeP,
pubmed-author:LanduytWillyW,
pubmed-author:LieuwesNatasjaN,
pubmed-author:MagagninMichaël GMG,
pubmed-author:WepplerSherry ASA,
pubmed-author:WoutersBradly GBG
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
73
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1219-27
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pubmed:meshHeading |
pubmed-meshheading:19251093-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19251093-Animals,
pubmed-meshheading:19251093-Cell Hypoxia,
pubmed-meshheading:19251093-Cell Survival,
pubmed-meshheading:19251093-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:19251093-Female,
pubmed-meshheading:19251093-Gene Knockout Techniques,
pubmed-meshheading:19251093-Glioblastoma,
pubmed-meshheading:19251093-HeLa Cells,
pubmed-meshheading:19251093-Humans,
pubmed-meshheading:19251093-Mice,
pubmed-meshheading:19251093-Mice, Nude,
pubmed-meshheading:19251093-Phosphoproteins,
pubmed-meshheading:19251093-Protein Biosynthesis,
pubmed-meshheading:19251093-Radiation Dosage,
pubmed-meshheading:19251093-Radiation Tolerance,
pubmed-meshheading:19251093-Transplantation, Heterologous
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance.
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pubmed:affiliation |
Department of Radiation Oncology (Maastro Laboratory), GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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