| pubmed-article:19250188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19250188 | lifeskim:mentions | umls-concept:C0679215 | lld:lifeskim |
| pubmed-article:19250188 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19250188 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19250188 | lifeskim:mentions | umls-concept:C0162340 | lld:lifeskim |
| pubmed-article:19250188 | lifeskim:mentions | umls-concept:C0046725 | lld:lifeskim |
| pubmed-article:19250188 | pubmed:dateCreated | 2009-3-2 | lld:pubmed |
| pubmed-article:19250188 | pubmed:abstractText | Steroid signaling involves specific receptors that mediate genomic effects and many further proteins responsible for fast nongenomic activities. Metabolism at the position 17 of the steroid scaffold plays a pivotal role in the final regulation of the biological potency of steroid hormones. Enzymes responsible for that, the 17beta-hydroxysteroid dehydrogenases (17beta-HSD), act as carbonyl reductases and require cofactors for their catalytic activity. There is a substantial amount of evidence that human 17beta-HSDs are as well involved in the metabolic pathways of retinoids and fatty acid beyond that which has so far been anticipated. At present fourteen 17beta-HSDs have been annotated and characterized, and more might follow. Many of 17beta-HSDs have been shown to be involved in the pathogenesis of human disorders and are targets for therapeutic intervention. Strategies on deciphering the physiological role of the 17beta-HSD and the genetic predisposition for associated diseases will be presented involving analyses of animal models. | lld:pubmed |
| pubmed-article:19250188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19250188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250188 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19250188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19250188 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19250188 | pubmed:issn | 1749-6632 | lld:pubmed |
| pubmed-article:19250188 | pubmed:author | pubmed-author:MöllerGabriel... | lld:pubmed |
| pubmed-article:19250188 | pubmed:author | pubmed-author:AdamskiJerzyJ | lld:pubmed |
| pubmed-article:19250188 | pubmed:author | pubmed-author:MeierMarcM | lld:pubmed |
| pubmed-article:19250188 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19250188 | pubmed:volume | 1155 | lld:pubmed |
| pubmed-article:19250188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19250188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19250188 | pubmed:pagination | 15-24 | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:meshHeading | pubmed-meshheading:19250188... | lld:pubmed |
| pubmed-article:19250188 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19250188 | pubmed:articleTitle | Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease. | lld:pubmed |
| pubmed-article:19250188 | pubmed:affiliation | Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany. | lld:pubmed |
| pubmed-article:19250188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19250188 | pubmed:publicationType | Review | lld:pubmed |
