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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-31
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pubmed:abstractText |
Invasive pancreatic ductal adenocarcinoma is thought to originate from duct-like lesions called pancreatic intraepithelial neoplasia (PanIN). PanINs progress from low grade (PanIN-1) to high grade (PanIN-3) as the cells attain molecular alterations to key regulatory genes, including activating mutations in the KRAS protooncogene. Despite a well-documented progression model, our knowledge of the initiator cells of PanINs and the transcriptional networks and signaling pathways that impact PanIN formation remains incomplete.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19249398-10820318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19249398-10955772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19249398-11159909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19249398-11342768,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19249398-9299439
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1368-78
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pubmed:dateRevised |
2010-12-17
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pubmed:meshHeading |
pubmed-meshheading:19249398-Animals,
pubmed-meshheading:19249398-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:19249398-Carcinoma in Situ,
pubmed-meshheading:19249398-Cell Transformation, Neoplastic,
pubmed-meshheading:19249398-Cells, Cultured,
pubmed-meshheading:19249398-Disease Models, Animal,
pubmed-meshheading:19249398-Disease Progression,
pubmed-meshheading:19249398-Mice,
pubmed-meshheading:19249398-Mice, Knockout,
pubmed-meshheading:19249398-Mice, Transgenic,
pubmed-meshheading:19249398-Pancreatic Neoplasms,
pubmed-meshheading:19249398-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:19249398-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19249398-Receptors, Notch,
pubmed-meshheading:19249398-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia.
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pubmed:affiliation |
Department of Biological Sciences and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907-2064, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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