| pubmed-article:19249278 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19249278 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:19249278 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:19249278 | lifeskim:mentions | umls-concept:C0037313 | lld:lifeskim |
| pubmed-article:19249278 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19249278 | pubmed:dateCreated | 2009-3-2 | lld:pubmed |
| pubmed-article:19249278 | pubmed:abstractText | Cortico-hippocampal interactions during sleep are believed to reorganize neural circuits in support of memory consolidation. However, spike-timing relationships across cortico-hippocampal networks-key determinants of synaptic changes-are poorly understood. Here we show that cells in prefrontal cortex fire consistently within 100 ms after hippocampal cells in naturally sleeping animals. This provides evidence at the single cell-pair level for highly consistent directional interactions between these areas within the window of plasticity. Moreover, these interactions are state dependent: they are driven by hippocampal sharp-wave/ripple (SWR) bursts in slow-wave sleep (SWS) and are sharply reduced during REM sleep. Finally, prefrontal responses are nonlinear: as the strength of hippocampal bursts rises, short-latency prefrontal responses are augmented by increased spindle band activity and a secondary peak approximately 100 ms later. These findings suggest that SWR events are atomic units of hippocampal-prefrontal communication during SWS and that the coupling between these areas is highly attenuated during REM sleep. | lld:pubmed |
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| pubmed-article:19249278 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19249278 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19249278 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19249278 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19249278 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19249278 | pubmed:issn | 1097-4199 | lld:pubmed |
| pubmed-article:19249278 | pubmed:author | pubmed-author:GuMingM | lld:pubmed |
| pubmed-article:19249278 | pubmed:author | pubmed-author:SiapasAthanas... | lld:pubmed |
| pubmed-article:19249278 | pubmed:author | pubmed-author:LubenovEvguen... | lld:pubmed |
| pubmed-article:19249278 | pubmed:author | pubmed-author:WierzynskiCas... | lld:pubmed |
| pubmed-article:19249278 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19249278 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:19249278 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:19249278 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19249278 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19249278 | pubmed:pagination | 587-96 | lld:pubmed |
| pubmed-article:19249278 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19249278 | pubmed:meshHeading | pubmed-meshheading:19249278... | lld:pubmed |
| pubmed-article:19249278 | pubmed:meshHeading | pubmed-meshheading:19249278... | lld:pubmed |
| pubmed-article:19249278 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19249278 | pubmed:articleTitle | State-dependent spike-timing relationships between hippocampal and prefrontal circuits during sleep. | lld:pubmed |
| pubmed-article:19249278 | pubmed:affiliation | Computation and Neural Systems Program, Division of Biology, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA. | lld:pubmed |
| pubmed-article:19249278 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19249278 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19249278 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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