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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-6
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pubmed:abstractText |
Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1432-0428
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
850-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19247628-Adipose Tissue,
pubmed-meshheading:19247628-Adult,
pubmed-meshheading:19247628-Aged,
pubmed-meshheading:19247628-Alternative Splicing,
pubmed-meshheading:19247628-Cadaver,
pubmed-meshheading:19247628-Diabetes Mellitus, Type 2,
pubmed-meshheading:19247628-Exons,
pubmed-meshheading:19247628-Female,
pubmed-meshheading:19247628-Genetic Variation,
pubmed-meshheading:19247628-Humans,
pubmed-meshheading:19247628-Islets of Langerhans,
pubmed-meshheading:19247628-Lymphocytes,
pubmed-meshheading:19247628-Male,
pubmed-meshheading:19247628-Middle Aged,
pubmed-meshheading:19247628-Muscle, Skeletal,
pubmed-meshheading:19247628-RNA,
pubmed-meshheading:19247628-Reference Values,
pubmed-meshheading:19247628-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19247628-TCF Transcription Factors,
pubmed-meshheading:19247628-Tissue Donors,
pubmed-meshheading:19247628-Transcription, Genetic,
pubmed-meshheading:19247628-Transcription Factor 7-Like 2 Protein
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pubmed:year |
2009
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pubmed:articleTitle |
Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
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pubmed:affiliation |
Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, Malmö, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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