Source:http://linkedlifedata.com/resource/pubmed/id/19247371
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2009-4-28
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| pubmed:abstractText |
Genetic factors are important in the development of metabolic syndrome. However, the genetic background of metabolic syndrome remains unclear. We screened polymorphisms in 85 obesity-related genes to determine which may be associated with metabolic syndrome. A total of 336 single-nucleotide polymorphisms (SNPs) in 85 genes selected from the JSNP database were genotyped. We conducted case-control association analyses using patients with metabolic syndrome (n=1080) and control individuals (n=528) who had no risk of the metabolic syndrome. Three SNPs in the McKusick-Kaufman syndrome (MKKS) gene were significantly related to metabolic syndrome by case-control association study; rs1545 (odds ratio (OR) adjusted for age and gender, 1.45; 95% confidence interval (CI), 1.21-1.74; P=0.000043 (additive model)); rs1547 (OR, 1.45; 95% CI, 1.21-1.74; P=0.000041); and rs2294901 (OR, 1.46; 95% CI, 1.22-1.75; P=0.000033). We selected five tag SNPs (rs2294901, rs221667, rs6133922, rs6077785 and rs6108572) in the MKKS gene. They were in one linkage disequilibrium (LD) block and rs6133922 (P=0.00042), rs6077785 (P=0.000013) and rs6108572 (P=0.000019) as well as rs2294901 were significantly associated with metabolic syndrome. TGAAA haplotype was protective against the metabolic syndrome (P=0.0074), and CCGTT haplotype was susceptible (P=0.00070) to the metabolic syndrome. Our data suggest that genetic variations at MKKS gene influence the risk of metabolic syndrome.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1435-232X
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| pubmed:author |
pubmed-author:FunahashiTohruT,
pubmed-author:HamaguchiKazuyukiK,
pubmed-author:HanafusaToshiakiT,
pubmed-author:HottaKikukoK,
pubmed-author:ItohNaotoN,
pubmed-author:KamataniNaoyukiN,
pubmed-author:KamoharaSeikaS,
pubmed-author:KomatsuRyoyaR,
pubmed-author:KotaniKazuakiK,
pubmed-author:MasuzakiHiroakiH,
pubmed-author:MatsuzawaYujiY,
pubmed-author:MineoIkuoI,
pubmed-author:MiyazakiShigeruS,
pubmed-author:NakajimaAtsushiA,
pubmed-author:NakamuraTakahiroT,
pubmed-author:NakamuraYusukeY,
pubmed-author:NakaoKazuwaK,
pubmed-author:NakataYoshioY,
pubmed-author:OikawaShinichiS,
pubmed-author:SakataToshiieT,
pubmed-author:TakahashiAtsushiA,
pubmed-author:TakahashiHiroshiH,
pubmed-author:TakasakiJunichiJ,
pubmed-author:TanakaKiyojiK,
pubmed-author:TokunagaKatsutoK,
pubmed-author:WildD JDJ,
pubmed-author:YamadaKentaroK,
pubmed-author:YonedaMasatoM,
pubmed-author:YoshimatsuHironobuH
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
230-5
|
| pubmed:dateRevised |
2010-4-8
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| pubmed:meshHeading |
pubmed-meshheading:19247371-Abnormalities, Multiple,
pubmed-meshheading:19247371-Female,
pubmed-meshheading:19247371-Gene Frequency,
pubmed-meshheading:19247371-Genetic Predisposition to Disease,
pubmed-meshheading:19247371-Genetic Testing,
pubmed-meshheading:19247371-Group II Chaperonins,
pubmed-meshheading:19247371-Haplotypes,
pubmed-meshheading:19247371-Humans,
pubmed-meshheading:19247371-Linkage Disequilibrium,
pubmed-meshheading:19247371-Male,
pubmed-meshheading:19247371-Metabolic Syndrome X,
pubmed-meshheading:19247371-Middle Aged,
pubmed-meshheading:19247371-Obesity,
pubmed-meshheading:19247371-Polymorphism, Single Nucleotide,
pubmed-meshheading:19247371-Regression Analysis,
pubmed-meshheading:19247371-Reproducibility of Results,
pubmed-meshheading:19247371-Syndrome
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome.
|
| pubmed:affiliation |
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Kanagawa, Japan. kikuko@src.riken.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|