Source:http://linkedlifedata.com/resource/pubmed/id/19247282
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2009-7-8
|
| pubmed:abstractText |
The objective of the study was to examine the association between a functional 4 bp proinsulin gene insertion polymorphism (IVS-69), fasting insulin concentrations, and body composition in black South African women. Body composition, body fat distribution, fasting glucose and insulin concentrations, and IVS-69 genotype were measured in 115 normal-weight (BMI<25 kg/m2) and 138 obese (BMI>or=30 kg/m2) premenopausal women. The frequency of the insertion allele was significantly higher in the class 2 obese (BMI>or=35 kg/m2) compared with the normal-weight group (P=0.029). Obese subjects with the insertion allele had greater fat mass (42.3+/-0.9 vs. 38.9+/-0.9 kg, P=0.034) and fat-free soft tissue mass (47.4+/-0.6 vs. 45.1+/-0.6 kg, P=0.014), and more abdominal subcutaneous adipose tissue (SAT, 595+/-17 vs. 531+/-17 cm2, P=0.025) but not visceral fat (P=0.739), than obese homozygotes for the wild-type allele. Only SAT was greater in normal-weight subjects with the insertion allele (P=0.048). There were no differences in fasting insulin or glucose levels between subjects with the insertion allele or homozygotes for the wild-type allele in the normal-weight or obese groups. In conclusion, the 4 bp proinsulin gene insertion allele is associated with extreme obesity, reflected by greater fat-free soft tissue mass and fat mass, particularly SAT, in obese black South African women.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1930-7381
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| pubmed:author |
pubmed-author:BaumgartenIngridI,
pubmed-author:BermanPeterP,
pubmed-author:CollinsMalcolmM,
pubmed-author:FaulenbachMirjam VMV,
pubmed-author:GoedeckeJulia HJH,
pubmed-author:JenningsCourtney LCL,
pubmed-author:JoffeYaelY,
pubmed-author:KahnSteven ESE,
pubmed-author:LambertEstelle VEV,
pubmed-author:LevittNaomi SNS,
pubmed-author:SeoigheCathalC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1298-300
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19247282-Adiposity,
pubmed-meshheading:19247282-African Continental Ancestry Group,
pubmed-meshheading:19247282-Blood Glucose,
pubmed-meshheading:19247282-Body Composition,
pubmed-meshheading:19247282-Case-Control Studies,
pubmed-meshheading:19247282-Fasting,
pubmed-meshheading:19247282-Female,
pubmed-meshheading:19247282-Gene Frequency,
pubmed-meshheading:19247282-Genotype,
pubmed-meshheading:19247282-Heterozygote,
pubmed-meshheading:19247282-Homozygote,
pubmed-meshheading:19247282-Humans,
pubmed-meshheading:19247282-Insulin,
pubmed-meshheading:19247282-Mutagenesis, Insertional,
pubmed-meshheading:19247282-Obesity,
pubmed-meshheading:19247282-Phenotype,
pubmed-meshheading:19247282-Polymorphism, Genetic,
pubmed-meshheading:19247282-Premenopause,
pubmed-meshheading:19247282-Proinsulin,
pubmed-meshheading:19247282-Severity of Illness Index,
pubmed-meshheading:19247282-South Africa,
pubmed-meshheading:19247282-Subcutaneous Fat
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Association between the 4 bp proinsulin gene insertion polymorphism (IVS-69) and body composition in black South African women.
|
| pubmed:affiliation |
Division of Chemical Pathology, UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa. peter.berman@uct.ac.za
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|