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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-4-15
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pubmed:abstractText |
A genome-wide scan in unrelated US Caucasians identified rs7001819 upstream of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) and multiple variants within catenin (cadherin-associated protein), beta-like 1 (CTNNBL1) to associate strongly with body mass index (BMI). The most significantly associating variants within CTNNBL1 including rs6013029 and rs6020846 were additionally confirmed to associate with morbid obesity in a French Caucasian case-control sample. The aim of this study was to investigate the impact of these three variants on obesity, through analyses of obesity-related quantitative traits, and case-control studies in large study samples of Danes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19245693-Adult,
pubmed-meshheading:19245693-Aged,
pubmed-meshheading:19245693-Alleles,
pubmed-meshheading:19245693-Apoptosis Regulatory Proteins,
pubmed-meshheading:19245693-Body Mass Index,
pubmed-meshheading:19245693-Case-Control Studies,
pubmed-meshheading:19245693-Cohort Studies,
pubmed-meshheading:19245693-Denmark,
pubmed-meshheading:19245693-Farnesyl-Diphosphate Farnesyltransferase,
pubmed-meshheading:19245693-Female,
pubmed-meshheading:19245693-Genome-Wide Association Study,
pubmed-meshheading:19245693-Humans,
pubmed-meshheading:19245693-Male,
pubmed-meshheading:19245693-Middle Aged,
pubmed-meshheading:19245693-Nuclear Proteins,
pubmed-meshheading:19245693-Obesity,
pubmed-meshheading:19245693-Quantitative Trait, Heritable
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pubmed:year |
2009
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pubmed:articleTitle |
Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.
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pubmed:affiliation |
Steno Diabetes Center, Gentofte, Denmark. cila@novonordisk.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
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