Linked Life Data

1924560

Source:http://linkedlifedata.com/resource/pubmed/id/1924560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-11-21
pubmed:abstractText
A new approach for tissue creation using synthetic biocompatible and biodegradable polymers as templates onto which cells are seeded is presented. This report concerns the generation of homogeneous plates of stable mature cartilage in vivo. The delivery of chondrocytes on synthetic polymers configured to provide a large surface area for cell attachment and thus to allow cell function and survival by diffusion of nutrients has resulted in the creation of macroscopic plates of up to 100 mg of new cartilage subcutaneously in 19 of 21 animals. The approximate dimensions and configuration of the original templates were maintained as new cartilage was formed and the polymers resorbed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0032-1052
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
753-9
pubmed:dateRevised
2011-2-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation.
pubmed:affiliation
Department of Anaesthesiology, Massachusetts General Hospital, Boston.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't