Source:http://linkedlifedata.com/resource/pubmed/id/19243953
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2009-3-20
|
| pubmed:abstractText |
By combining the structural features of acridone based anti-cancer drugs (like amsacrine) and MDR modulator propafenone, acridones with hydroxyl amine chain at N-10 have been designed and synthesized. These molecules exhibit appreciable interactions with p-gp and Mg(2+) indicating their suitability to modulate p-gp mediated multi drug resistance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1464-3391
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2423-7
|
| pubmed:meshHeading |
pubmed-meshheading:19243953-Acridones,
pubmed-meshheading:19243953-Drug Design,
pubmed-meshheading:19243953-Drug Resistance, Multiple,
pubmed-meshheading:19243953-Magnesium,
pubmed-meshheading:19243953-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19243953-Models, Molecular,
pubmed-meshheading:19243953-P-Glycoprotein,
pubmed-meshheading:19243953-Spectrometry, Mass, Fast Atom Bombardment
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+.
|
| pubmed:affiliation |
Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India. palwinder_singh_2000@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|