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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-12-6
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pubmed:abstractText |
A potentially life-threatening hypersensitive reaction occurs in association with initiation of HIV nucleoside analogue abacavir therapy in 4 to 8% of patients. Preliminary studies appear to confirm the role of the immune system in abacavir hypersensitivity. The reaction is possibly the result of presentation of drug peptides onto HLA, that may induce a pathogenic T-cell response. Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele and prospective HLA-B*5701 genetic screening has now been instituted in clinical practice to reduce the risk of hypersensitivity reaction.
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pubmed:language |
fre
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1768-3114
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2009 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e95-100
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pubmed:meshHeading |
pubmed-meshheading:19243901-Alleles,
pubmed-meshheading:19243901-Anti-HIV Agents,
pubmed-meshheading:19243901-Antigen Presentation,
pubmed-meshheading:19243901-Dideoxynucleosides,
pubmed-meshheading:19243901-Drug Hypersensitivity,
pubmed-meshheading:19243901-Gene Frequency,
pubmed-meshheading:19243901-Genes, MHC Class I,
pubmed-meshheading:19243901-Genetic Predisposition to Disease,
pubmed-meshheading:19243901-Genetic Testing,
pubmed-meshheading:19243901-HIV Reverse Transcriptase,
pubmed-meshheading:19243901-HLA-B Antigens,
pubmed-meshheading:19243901-Humans,
pubmed-meshheading:19243901-Peptide Fragments,
pubmed-meshheading:19243901-Polymerase Chain Reaction,
pubmed-meshheading:19243901-Reverse Transcriptase Inhibitors,
pubmed-meshheading:19243901-Sequence Analysis, DNA,
pubmed-meshheading:19243901-T-Lymphocytes, Cytotoxic
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pubmed:year |
2010
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pubmed:articleTitle |
[HLA-B*5701 and abacavir hypersensitivity reaction].
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pubmed:affiliation |
Laboratoire de biochimie, hôpital d'instruction des armées Bégin, 69, avenue de Paris, 94163 Saint-Mandé cedex, France. a_servonnet@yahoo.fr
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pubmed:publicationType |
Journal Article,
English Abstract
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