Linked Life Data

19243499

Source:http://linkedlifedata.com/resource/pubmed/id/19243499

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-4-3
pubmed:abstractText
Immunomodulators that induce local endogenous interferon-alpha (IFN-alpha) production by plasmacytoid dendritic cells (pDCs) may offer new strategies for the treatment of patients chronically infected with the hepatitis C virus (HCV). However, such an approach may be compromised if reports are true that IFN-alpha production by pDCs from patients with chronic HCV (cHCV) is profoundly impaired. To address the question of pDC dysfunction in cHCV more definitively, in the present study a panel of four prototypic synthetic agonists of toll-like receptor 7 (TLR7) or TLR9 were administered in vitro to pDCs purified from cHCV patients and from normal uninfected donors and their responses compared in terms of not only IFN-alpha production but also the global expression of other cytokines and phenotypic maturation. Plasmacytoid DCs from uninfected donors produced substantial levels of IFN-alpha in response to three of the four agonists and yet only one TLR9 agonist, a class C CpG oligodeoxynucleotide (ODN), induced robust IFN-alpha production by pDCs from cHCV patients. Proinflammatory cytokine production and phenotypic maturation in response to all four agonists was equivalent in infected and uninfected pDCs. These data point to a profound but selective defect in IFN-alpha production by pDCs from cHCV donors. Nonetheless, a class C CpG ODN successfully induced robust IFN-alpha production, suggesting that this class of TLR9 agonist may have utility as a future immunotherapeutic for the treatment of chronic HCV infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-10358757, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-11207245, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-11325598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-11449369, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-11592079, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-11812998, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12407599, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12668648, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12707322, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12738885, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12773511, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12778481, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-12960254, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-14991609, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15034038, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15067070, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15116301, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15123819, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15320906, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15529255, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15546383, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15591070, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15592841, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15629508, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15665823, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15726647, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15771572, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15782389, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15800576, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-15995965, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-16107837, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-16122679, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-16293610, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-16424890, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-16892183, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17082589, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17239662, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17275323, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17371961, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17372001, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17467113, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17607015, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17893202, http://linkedlifedata.com/resource/pubmed/commentcorrection/19243499-17935622
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1365-2893
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C.
pubmed:affiliation
iQur Ltd, Southampton General Hospital, Southampton, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't