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rdf:type |
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lifeskim:mentions |
umls-concept:C0013126,
umls-concept:C0017262,
umls-concept:C0021125,
umls-concept:C0025810,
umls-concept:C0034693,
umls-concept:C0185117,
umls-concept:C0205653,
umls-concept:C0332437,
umls-concept:C0392747,
umls-concept:C0521390,
umls-concept:C1415816,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2009-4-22
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pubmed:abstractText |
Methylphenidate (MPH) administration to adolescent rodents produces persistent region-specific changes in brain reward circuits and alterations of reward-based behavior. We show that these modifications include a marked increment of serotonin (5-hydroxy-tryptamine) receptor type 7 (Htr7) expression and synaptic contacts, mainly in the nucleus accumbens, and a reduction of basal behavioral impulsivity. We show that neural and behavioral consequences are functionally related: administration of a selective Htr7 antagonist fully counteracts the MPH-reduced impulsive behavior and enhances impulsivity when administered alone in naive rats. Agonist-induced activation of endogenous Htr7 significantly increases neurite length in striatal neuron primary cultures, thus suggesting plastic remodeling of neuronal morphology. The mixed Htr (1a/7) agonist, 8-OH-DPAT, reduces impulsive behavior in adolescent rats and in naive adults, whose impulsivity is enhanced by the Htr7 antagonist. In summary, behavioral pharmacology experiments show that Htr7 mediates self-control behavior, and brain primary cultures experiments indicate that this receptor may be involved in the underlying neural plasticity, through changes in neuronal cytoarchitecture.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1601-183X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
356-68
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19243449-Aging,
pubmed-meshheading:19243449-Animals,
pubmed-meshheading:19243449-Behavior, Animal,
pubmed-meshheading:19243449-Cell Enlargement,
pubmed-meshheading:19243449-Cells, Cultured,
pubmed-meshheading:19243449-Central Nervous System Stimulants,
pubmed-meshheading:19243449-Disease Models, Animal,
pubmed-meshheading:19243449-Female,
pubmed-meshheading:19243449-Impulsive Behavior,
pubmed-meshheading:19243449-Male,
pubmed-meshheading:19243449-Methylphenidate,
pubmed-meshheading:19243449-Neurites,
pubmed-meshheading:19243449-Neuronal Plasticity,
pubmed-meshheading:19243449-Neurons,
pubmed-meshheading:19243449-Nucleus Accumbens,
pubmed-meshheading:19243449-Presynaptic Terminals,
pubmed-meshheading:19243449-Rats,
pubmed-meshheading:19243449-Rats, Wistar,
pubmed-meshheading:19243449-Receptors, Serotonin,
pubmed-meshheading:19243449-Reward,
pubmed-meshheading:19243449-Serotonin,
pubmed-meshheading:19243449-Serotonin Antagonists,
pubmed-meshheading:19243449-Serotonin Receptor Agonists
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pubmed:year |
2009
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pubmed:articleTitle |
Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology.
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pubmed:affiliation |
Institute of Genetics and Biophysics A. Buzzati Traverso, CNR, Naples, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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