Linked Life Data

19243017

Source:http://linkedlifedata.com/resource/pubmed/id/19243017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2009-8-31
pubmed:abstractText
Neural crest (NC) cells are a multipotent, highly migratory cell population that generates most of the components of the peripheral nervous system (PNS), including the glial Schwann cells (SC) and boundary cap (BC) cells. These latter cells are located at the interface between the central nervous system and PNS, at the exit/entry points of ventral motor/dorsal sensory axons and give rise to all SC in the nerve roots and to a subset of nociceptive neurons and satellite cells in the dorsal root ganglia. In the present study we have compared BC cells with two closely related cell types, NC and Schwann cell precursors (SCpr), by RNA profiling. This led to the definition of a set of 10 genes that show specific expression in BC cells and/or in their derivatives along the nerve roots. Analysis of the expression of these genes during mouse development revealed novel features, of those most important are: (i) dorsal and ventral nerve root BC cell derivatives express different sets of genes, suggesting that they have distinct properties; (ii) these cells undergo major modifications in their gene expression pattern between embryonic days 14.5 and 17.5, possibly linked to the SCpr-immature Schwann cell transition; (iii) nerve roots SC differ from more distal SC not only in their origins and locations, but also in their gene expression patterns. In conclusion, the identification of these novel makers opens the way for a detailed characterization of BC cells in both mouse and man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1098-1136
pubmed:author
pubmed:copyrightInfo
(c) 2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1450-7
pubmed:meshHeading
pubmed-meshheading:19243017-Animals, pubmed-meshheading:19243017-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:19243017-Biological Markers, pubmed-meshheading:19243017-Early Growth Response Protein 2, pubmed-meshheading:19243017-Gene Expression Regulation, Developmental, pubmed-meshheading:19243017-Immunohistochemistry, pubmed-meshheading:19243017-In Situ Hybridization, pubmed-meshheading:19243017-Mice, pubmed-meshheading:19243017-Mice, Transgenic, pubmed-meshheading:19243017-Neural Crest, pubmed-meshheading:19243017-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:19243017-RNA, pubmed-meshheading:19243017-Receptors, Atrial Natriuretic Factor, pubmed-meshheading:19243017-Repressor Proteins, pubmed-meshheading:19243017-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19243017-Ribosomal Proteins, pubmed-meshheading:19243017-Schwann Cells, pubmed-meshheading:19243017-Spinal Nerve Roots, pubmed-meshheading:19243017-Stem Cells
pubmed:year
2009
pubmed:articleTitle
Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.
pubmed:affiliation
INSERM, CNRS, IFR36, Plate-forme Transcriptome, 46 rue d'Ulm, 75230 Paris Cedex 05, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't