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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1991-10-31
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pubmed:abstractText |
We describe a physical map of the end of the long arm of the human X chromosome encompassing the region from Xq27.2 to the q telomere, inclusive of the chromosomal band Xq28. This region is of particular interest, since it contains the highest density of genes associated with genetic diseases. The map covers a total of 12 megabases (Mb) of DNA and extends from the telomere to 3 Mb beyond the most likely position of the fragile X mutation, defined by a cluster of translocation breakpoints in somatic cell hybrids. The map determines order and position of loci throughout the Xq28 region and localizes cell line breakpoints marking the fragile X region to an interval of 300-700 kilobases between 8 and 8.7 Mb proximal of the Xq telomere.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-1670748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-1672291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-1969225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-1974122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-1985451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2208276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2339126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2501212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2561974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2564838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2565870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2569270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2573953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2574000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2574147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2589319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2676379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2744766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2880670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2882476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2883888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2906041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-2937147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-3482420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-3502701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-3515319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-3545058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-3603029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-3953659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-4080545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-5794013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-6090124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-6324578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-6326147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-6438525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-6438526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1924290-6712153
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:geneSymbol |
F8,
G6PD,
GABRA3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8302-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1991
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pubmed:articleTitle |
Physical map of human Xq27-qter: localizing the region of the fragile X mutation.
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pubmed:affiliation |
Deutsches Krebsforschungszentrum, Institut für Virusforschung, Heidelberg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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