Linked Life Data

19239357

Source:http://linkedlifedata.com/resource/pubmed/id/19239357

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-25
pubmed:abstractText
Regulatory T cells (Tregs) may play an important role in the immunopathology of chronic HIV-1 infection due to their potent suppressive activity of both T cell activation and effector function. To investigate the correlation between Tregs and immune activation during untreated chronic HIV-1 infection, we conducted a nested case-control study within the Multicenter AIDS Cohort Study (MACS). Twenty HIV-1-infected fast progressors (FP) and 40 slow progressors (SP) were included in our study using risk-set sampling. Nine age-matched HIV-1-uninfected men (UI) were also included. Cryopreserved peripheral blood mononuclear cells (PMBCs) were tested using flow cytometry analyses. We identified Tregs as Foxp3+CD25+CD4+ T cells and assessed the activation of CD4+ and CD8+ T cells by the expression of CD38, HLADR, or both markers simultaneously. There is a relative expansion of Tregs during HIV-1 infection, which is associated with disease progression. The increased CD38 expression on both CD4+ and CD8+ T cells expressed as either percentage or median fluorescence intensity (MFI) and the elevated proportion of CD8+ T cells that is HLADR+CD38+ were all associated with rapid HIV-1 progression. Counter to the assumed role of Tregs as the suppressors of activation, the expansion of Tregs was positively correlated with CD4+ T cell activation among HIV-1-infected fast progressors. The high level of Tregs associated with rapid HIV progression may suggest a detrimental role of these cells in the immune control of HIV-1 infection.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-10068581, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-10837065, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-10850488, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11137992, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11137993, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11138001, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11160730, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11466340, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11483607, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11722629, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-11917238, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12413528, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12469117, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12522256, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12612578, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12612581, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12893750, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-12960820, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-14597769, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-14676299, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-14963140, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15030773, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15032588, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15067051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15226269, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15252446, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15271794, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15280419, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15749840, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15778406, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15780990, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-15905668, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-16010156, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-16044000, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-16453267, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-16868450, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-16902147, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-17200412, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-2053595, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-2570479, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-3300281, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-7907956, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-7930717, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-8809474, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-9358102, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-9557672, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-9773872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19239357-9773881
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1931-8405
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-91
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
More...