Linked Life Data

19239230

Source:http://linkedlifedata.com/resource/pubmed/id/19239230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-3-19
pubmed:abstractText
We recently discovered the isoform selective RAR beta 2 ligand 4'-octyl-4-biphenylcarboxylic acid (3, AC-55649). Although 3 is highly potent at RAR beta 2 and displays excellent selectivity, solubility issues make it unsuitable for drug development. Herein we describe the exploration of the SAR in a biphenyl and a phenylthiazole series of analogues of 3. This ultimately led to the design of 28, a novel, orally available ligand with excellent isoform selectivity for the RAR beta 2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1520-4804
pubmed:author
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1540-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.
pubmed:affiliation
ACADIA Pharmaceuticals AB, Medeon Science Park, S-205 12 Malmo, Sweden.
pubmed:publicationType
Journal Article