|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2009-3-31
|
|
pubmed:abstractText |
Patients with bone metastases and elevated urinary N-telopeptide (uNTx), representing excessive bone resorption, are at increased risk for skeletal-related events (SREs), cancer progression, and death. Osteoclast-mediated bone resorption is regulated by RANKL. We evaluated the effect of denosumab, a fully human monoclonal antibody against RANKL, in patients with bone metastases and elevated uNTx levels despite ongoing intravenous (IV) bisphosphonate (BP) therapy.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1527-7755
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1564-71
|
|
pubmed:meshHeading |
pubmed-meshheading:19237632-Aged,
pubmed-meshheading:19237632-Antibodies, Monoclonal,
pubmed-meshheading:19237632-Bone Density Conservation Agents,
pubmed-meshheading:19237632-Bone Neoplasms,
pubmed-meshheading:19237632-Bone Resorption,
pubmed-meshheading:19237632-Breast Neoplasms,
pubmed-meshheading:19237632-Collagen Type I,
pubmed-meshheading:19237632-Diphosphonates,
pubmed-meshheading:19237632-Female,
pubmed-meshheading:19237632-Humans,
pubmed-meshheading:19237632-Male,
pubmed-meshheading:19237632-Middle Aged,
pubmed-meshheading:19237632-Multiple Myeloma,
pubmed-meshheading:19237632-Peptides,
pubmed-meshheading:19237632-Prostatic Neoplasms,
pubmed-meshheading:19237632-RANK Ligand
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates.
|
|
pubmed:affiliation |
Department of Medicine, Institut Gustave Roussy, University of Paris XI, Villejuif, France. fizazi@igr.fr
|
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II
|
