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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1991-11-4
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pubmed:databankReference |
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pubmed:abstractText |
The Staphylococcus aureus chromosomal gene plaC, identified by mutations such as plaC1 that lead to the amplification of plasmid pT181, has been cloned and sequenced. The plaC gene encodes a protein with high similarity (79% identity) with the vegetative sigma factor of Bacillus subtilis, sigA, suggesting that it acts as an RNA polymerase sigma factor in S.aureus. The plaC1 mutation was found to be a C to T transition leading to a proline to serine substitution at amino acid residue 209 of the protein. In other sigma factors this region of the protein is involved in specific recognition of the -10 promoter sequence. The change in sigma factor activity due to this mutation is characterized by its strict specificity for a limited number of promoters and the rather high amplitude of the effect.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-107388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2457579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2478296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2500529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2579377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2661827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2661828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2788645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2846853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2852816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-2987246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-3052291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-3054119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-3086839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-3162770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-3957869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-4208895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-6287465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-6437809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-6499834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-6635012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-6927766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1923759-7007333
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
19
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pubmed:geneSymbol |
plaC
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4921-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1923759-Amino Acid Sequence,
pubmed-meshheading:1923759-Base Sequence,
pubmed-meshheading:1923759-Cloning, Molecular,
pubmed-meshheading:1923759-Escherichia coli,
pubmed-meshheading:1923759-Genes, Bacterial,
pubmed-meshheading:1923759-Molecular Sequence Data,
pubmed-meshheading:1923759-Mutation,
pubmed-meshheading:1923759-Plasmids,
pubmed-meshheading:1923759-Proline,
pubmed-meshheading:1923759-Promoter Regions, Genetic,
pubmed-meshheading:1923759-Restriction Mapping,
pubmed-meshheading:1923759-Serine,
pubmed-meshheading:1923759-Sigma Factor,
pubmed-meshheading:1923759-Staphylococcus aureus
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pubmed:year |
1991
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pubmed:articleTitle |
The Staphylococcus aureus chromosomal gene plaC, identified by mutations amplifying plasmid pT181, encodes a sigma factor.
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pubmed:affiliation |
Public Health Research Institute, New York, NY 10016.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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