| pubmed-article:1923519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C0072480 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1923519 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1923519 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1923519 | pubmed:dateCreated | 1991-11-1 | lld:pubmed |
| pubmed-article:1923519 | pubmed:abstractText | Two murine cell lines that overexpress v-sis/PDGF-2 were used to study the mechanism of cell transformation by SSV (simian sarcoma virus). In contrast to the parental cells that are phenotypically normal and serum-dependent for growth, v-sis-overexpressing cells grow in PDGF-free plasma medium, are unable to enter the G0 state and are highly tumorigenic. Analysis of the expression of some growth factor-induced early response genes in v-sis-overexpressing cells revealed: (a) high and constitutive c-myc mRNA levels in SSV-NRK cells; (b) unaltered levels of fra-1, fos B, jun B and krox 20 transcripts; (c) high and constitutive FOS staining due to c-FOS and FOS-related protein(s); (d) constitutive c-JUN and higher JUN D expression. These results are compatible with a model in which endogenous production of v-sis/PDGF-2 leads to deregulated expression of key cellular transregulators that, in turn, alter the cells' transcriptional program leading to the transformed state and malignancy. | lld:pubmed |
| pubmed-article:1923519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1923519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1923519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1923519 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1923519 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:1923519 | pubmed:author | pubmed-author:BravoRR | lld:pubmed |
| pubmed-article:1923519 | pubmed:author | pubmed-author:SonobeM HMH | lld:pubmed |
| pubmed-article:1923519 | pubmed:author | pubmed-author:ArmelinM SMS | lld:pubmed |
| pubmed-article:1923519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1923519 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1923519 | pubmed:geneSymbol | jun | lld:pubmed |
| pubmed-article:1923519 | pubmed:geneSymbol | fos | lld:pubmed |
| pubmed-article:1923519 | pubmed:geneSymbol | v-sis | lld:pubmed |
| pubmed-article:1923519 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:1923519 | pubmed:geneSymbol | fra-1 | lld:pubmed |
| pubmed-article:1923519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1923519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1923519 | pubmed:pagination | 1531-7 | lld:pubmed |
| pubmed-article:1923519 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1923519 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1923519 | pubmed:articleTitle | Imbalanced expression of cellular nuclear oncogenes caused by v-sis/PDGF-2. | lld:pubmed |
| pubmed-article:1923519 | pubmed:affiliation | Departamento de Bioquímica, Universidade de São Paulo, Brazil. | lld:pubmed |
| pubmed-article:1923519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1923519 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1923519 | lld:pubmed |
